Name: SYT4抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： SYT4抗原（重組蛋白）

英文名稱： SYT4 Antigen (Recombinant Protein)

別名： HsT1192

儲存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to a region derived from 38-200 amino acids of human SYT4

技術(shù)規(guī)格

Full name:	synaptotagmin IV
Synonyms:	HsT1192
Swissprot:	Q9H2B2
Gene Accession:	BC036538
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus. The proximity of the Synaptotagmin IV gene to markers of several psychiatric disorders suggest an involvement of synaptotagmin IV in human disease. Synaptotagmin V is a dense-core vesicle-specific protein that regulates a specific type of calcium-regulated secretion. Synaptotagmin VI interacts with adaptor protein-2 in a calcium-independent manner. Synaptotagmin VII is widely expressed in non-neuronal tissues.

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