Name: PLAUR抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： PLAUR抗原（重組蛋白）

英文名稱(chēng)： PLAUR Antigen (Recombinant Protein)

別名： CD87; UPAR; URKR; U-PAR

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別：抗原

概述

Fusion protein corresponding to a region derived from 23-305 amino acids of human PLAUR

技術(shù)規(guī)格

Full name:	Plasminogen activator, urokinase receptor
Synonyms:	CD87; UPAR; URKR; U-PAR
Swissprot:	Q03405
Gene Accession:	BC002788
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

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