購(gòu)物車
幫助
021-54845833/15800441009
中文名稱 : 小鼠抗MAPK9單克隆抗體
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Background: |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
MAPK9 |
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Immunogen: |
Fusion protein of human MAPK9 |
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Full name: |
mitogen-activated protein kinase 9 (MAPK9), transcript variant JNK2-a1 |
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Synonyms: |
JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a |
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SwissProt: |
P45984 |
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IHC positive control: |
human pancreas tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
48 kDa |
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WB Positive control: |
HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates |
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WB Recommended dilution: |
200-1000 |
