中文名稱：兔抗ERCC1多克隆抗體

英文名稱： Anti-ERCC1 rabbit polyclonal antibody

別名： ERCC excision repair 1, endonuclease non-catalytic subunit UV20; COFS4; RAD10

相關(guān)類別： 一抗

抗原： ERCC1

儲(chǔ) 存： 冷凍（-20℃）

宿主： Rabbit

反應(yīng)種屬： Human, Mouse

標(biāo) 記物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Applications:

ELISA, IHC

Name of antibody:

ERCC1

Immunogen:

Synthetic peptide of human ERCC1

Full name:

ERCC excision repair 1, endonuclease non-catalytic subunit

Synonyms:

UV20; COFS4; RAD10

SwissProt:

P07992

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer;

IHC Recommend dilution:

25-100

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ELISA試劑盒

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生化試劑盒

細(xì)胞系

細(xì)胞庫

基礎(chǔ)培養(yǎng)基

完全培養(yǎng)基

原代細(xì)胞

細(xì)胞專用培養(yǎng)基

菌株

生化試劑

病理染色液

科研抗體

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血清

形態(tài)病理檢測

分子病理

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兔抗ERCC1多克隆抗體

Background:	The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Applications:	ELISA, IHC
Name of antibody:	ERCC1
Immunogen:	Synthetic peptide of human ERCC1
Full name:	ERCC excision repair 1, endonuclease non-catalytic subunit
Synonyms:	UV20; COFS4; RAD10
SwissProt:	P07992
ELISA Recommended dilution:	5000-10000
IHC positive control:	Human esophagus cancer;
IHC Recommend dilution:	25-100