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中文名稱： 兔抗H2AFX多克隆抗體
英文名稱： Anti-H2AFX (Ab-139) rabbit polyclonal antibody
別 名： H2AX; H2A.X; H2A/X
相關(guān)類別： 一抗
儲(chǔ) 存： 冷凍（-20℃） 避光
宿 主： Rabbit
抗 原： H2AFX
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
Background:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation
Applications:
WB, IHC, IF
Name of antibody:
H2AFX
Immunogen:
Synthetic peptide of human H2AFX (Ab-139)
Full name:
H2A histone family, member X
Synonyms：
H2AX; H2A.X; H2A/X
SwissProt:
P16104
IHC positive control:
Human breast carcinoma
IHC Recommend dilution:
50-100
WB Predicted band size:
15 kDa
WB Positive control:
HepG2 and 293 cells
WB Recommended dilution:
500-1000
IF Positive control:
Hela cells
IF Recommended dilution
100-200
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