購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：ZAP70抗原（重組蛋白）
英文名稱： ZAP70 Antigen (Recombinant Protein)
別 名： SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 420-619 amino acids of human ZAP70 |
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Full name: |
zeta chain of T cell receptor associated protein kinase 70 |
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Synonyms: |
SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70 |
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Swissprot: |
P43403 |
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Gene Accession: |
BC039039 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. |
