購物車
幫助
021-54845833/15800441009
中文名稱： KIF1C 抗原（重組蛋白）
英文名稱： KIF1C Antigen (Recombinant Protein)
別 名： kinesin family member 1C; SAX2; LTXS1; SATX2; SPAX2; SPG58
儲 存： 冷凍（-20℃）
相關類別： 抗原
概 述
|
Fusion protein corresponding to a region derived from 360-460 amino acids of human KIF1C |
|
Full name: |
kinesin family member 1C |
|
Synonyms: |
SAX2; LTXS1; SATX2; SPAX2; SPG58 |
|
Swissprot: |
O43896 |
|
Gene Accession: |
BC034993 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell . Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis . KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons . Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle . Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta . In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance. |
