中文名稱：STAT3抗原（重組蛋白）

英文名稱： STAT3 Antigen (Recombinant Protein)

儲存： 冷凍（-20℃）

相關類別： 抗原

概述

Fusion protein corresponding to a region derived from 421-768 amino acids of human STAT3

技術規格

Full name:

signal transducer and activator of transcription 3

Synonyms:

APRF; HIES; ADMIO; ADMIO1

Swissprot:

P40763

Gene Accession:

BC014482

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors and is required for murine fetal development. Research studies have shown that Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.

展開全部

STAT3抗原（重組蛋白）說明書
下載

欧美一级免费-欧美一级免费观看-欧美一级免费看-欧美一级免费片-jizzjizz大全-jizzjizz国产精品

021-54845833/15800441009

ELISA試劑盒

PCR試劑盒

生化試劑盒

細胞系

細胞庫

基礎培養基

完全培養基

原代細胞

細胞專用培養基

菌株

生化試劑

病理染色液

科研抗體

標準品

血清

形態病理檢測

分子病理

超微病理

產品中心

最新產品

相關文章

STAT3抗原（重組蛋白）

Full name:	signal transducer and activator of transcription 3
Synonyms:	APRF; HIES; ADMIO; ADMIO1
Swissprot:	P40763
Gene Accession:	BC014482
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors and is required for murine fetal development. Research studies have shown that Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways. Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage. It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain.