購(gòu)物車(chē)
幫助
021-54845833/15800441009
技術(shù)規(guī)格
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Background: |
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
PRMT6 |
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Immunogen: |
Fusion protein of human PRMT6 |
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Full name: |
protein arginine methyltransferase 6 |
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Synonyms: |
HRMT1L6 |
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SwissProt: |
Q96LA8 |
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IHC positive control: |
Human breast cancer |
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IHC Recommend dilution: |
100-200 |
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WB Predicted band size: |
42 kDa |
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WB Positive control: |
Hela and 293T cell lysates |
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WB Recommended dilution: |
1000-5000 |
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IF positive control: |
Hela cells |
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IF Recommend dilution: |
150-300 |
