購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
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Applications: |
WB |
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Name of antibody: |
KITLG |
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Immunogen: |
Synthetic peptide of human KITLG |
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Full name: |
KIT ligand |
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Synonyms： |
SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7 |
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SwissProt: |
P21583 |
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WB Predicted band size: |
31 kDa |
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WB Positive control: |
A549, A431, Hela and 3T3 cells |
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WB Recommended dilution: |
500-1000 |
